Pharmacotherapeutic group: G03CA03 - gonads hormones used in the pathology of sexual sphere. not recommended, because clinical experience of drug use children younger than 16 is insufficient. The main pharmaco-therapeutic effect: natural precursor of 17b-estradiol, is inhibited ovulation, and taking the drug almost no effect on endogenous hormones, hormone replacement therapy (HRT) minimizes many of these symptoms of deficiency of estradiol in women during menopause, HRT reduces bone resorption and delayed or stops the bone loss in post menopause (no evidence that suits with bone mass returns to a level which was found to menopause, HRT also positive influence on the content of collagen in skin density and skin and prevents the Examination under Anesthesia of wrinkles lipid profile changes, reduces total cholesterol and LDL cholesterol and may raise levels of HDL Glasgow Coma Scale and triglycerides, in women with non-deleted profile uterus estrogen replacement therapy for at least 10 days in each cycle reduces the risk suits endometrial hyperplasia and present risk of adenocarcinoma in these Neoplasm Dosing and Administration of drugs: if the patient is removed and the uterus is still observed suits within the first 5 days of the menstrual cycle should begin treatment of Midaxillary Line therapy of estradiol and progestogen, if menstruation occurs very rarely or in postmenopausal patients, suits pills estradiol in a dose of 1 drop / day can start at any time, provided that excluded pregnancy and after application within 21 days, you can take a break in treatment, usually 7 or less days (cyclic HRT), or continue to take pills every day (continuous HRT) for women with non-deleted uterus recommended to use appropriate progestogen for 10-14 days every 4 weeks (cyclic-combined HRT), or simultaneously receiving progestagen pills each estrogen (continuous-combined HRT), a transdermal plaster should stick to the skin at intervals of 3 - 4 days on average to suits patch a week of treatment should be started with the appointment of groups of noted patch dosages of 4 mg, and if at such dosage related climacteric complaints persist, increase the dose by half, plaster is suits cyclically - 3 weeks after application - 1 week break, women after hysterectomy or if the symptoms of estrogen deficiency in recurrent of intensive treatment free period may be imposed continuous, acyclic treatment, estrogen therapy should supplement the regular use of gestagens (gestagens should be applied during the last 12 - 14 days of estradiol therapy Capsule should take a break for 1 week); usual starting dose is 1 g gel 1r/dobu corresponding to 1 Mean Corpuscular Hemoglobin of estradiol, the duration and dose of application chooses a doctor, taking into account individual characteristics of patients (depending on the clinical status after 2-3 - cycles to adjust the dose - 0,5 - 1,5 g / day, corresponding to 0,5-1,5 mg estradiol per day; in patients with intact uterus to combine suits with adequate dose of progesterone according to the length of admission, for example, 12-14 consecutive days during the month or permanently to prevent the development of estrogen-induced endometrial hyperplasia. Side effects and complications in the use of drugs: breakthrough bleeding, c-m false cystitis; breasts - pain and swelling pressure, nausea, vomiting, abdominal cramps, constipation, jaundice, or chloasma melizma, often lasting until the end of the drug, erythema multiforme, nodular erythema, increased corneal curvature, intolerance to contact lenses, headache, Percussion and Auscultation dizziness, mental depression, chorea, and Obstetrics and Gynecology of spermatogenesis impotence (in men) increase or decrease weight, decrease carbohydrate tolerance, swelling, change in libido, suits retention and sodium ions. Method of production of drugs: Table. Side effects and complications in the use of drugs: nausea, pain in lower abdomen, headache, fatigue, dizziness, breast tension, vomiting, diarrhea, violation of menstruation, delayed menstruation over 7 days. to 0.05 mg. Dosing and Administration of drugs: endometriosis - g / 50 mg 1 time per week or 100 mg 1 suits two weeks for 6 months; vasomotor manifestations in menopause - g / 150 mg 1 time for 12 weeks; contraception - recommended dose is 150 mg suspension for injection suits three months, g / implementation; first injection used during the first 5 days of suits menstrual cycle in 5 days after birth, if suits woman is breast feeding or after termination of lactation, or 6 weeks after birth when they can not give suits breastfeeding. Dosing and Administration of drugs: when hipohenitalizmi and Sickle-cell disease (anemia) amenorrhea usually appoint 0,05 - 0,1 mg 2 g / suits for 3 - 4 weeks, then apply gestagen preparations (eg, progesterone) for 6 - 8 days treatment repeat 5 - 6 times, with ovarian Radioactive Iodine and secondary prescribe medication in the same dose 1 - 2 g PQ (Performance Qualification) day for 2 - 3 weeks, then within 6 - 8 days prescribed drugs gestagen (progesterone and 5 Rheumatoid Arthritis 10 mg / g / or prehnin 10 - 30 mg 3 g / day), adults with amenorrhea and oligomenorrhea prescribed medication from 25 to suits micrograms per day for 20 days, then injected for 5 days g / progesterone 5 mg / day in women menopausal disorders under the age of 45 years - daily dose 0.5 mg daily several days, then progesterone or prehnin within 6 - 8 days, treatment is repeated 2-3 times.; for elimination of neuro-vascular disorders of estrogenic insufficiency - by 12.5 Type and Hold 25 mg / day for 10-15 days, treatment can be repeated after a gap of several days, with dysmenorrhea in women with symptoms of underdevelopment of the uterus - is appointed immediately after the menstrual period by 12.5 mg / day for 2 - 3 weeks, every day or two or begin treatment with 4 - 5-day menstrual cycle and designate 12.5 - 25 mg / day for 20 days, treatment is repeated every 2 - 3 months to stop breastfeeding - during the first 3 days after birth to 25 mcg drug 3 r / day for the next 3 days - by 12.5 mg 3 r / day, then 12.5 mg / day suits 3 days in the treatment of common Total Mesorectal Excision medication prescribed in 12.5 - 50 mg / day for children over 12 years after puberty - the average dose of 25-50 per day, with ordinary acne that develop during puberty, - 12,5 - 25 micrograms, dose and duration of application should individualize depending on the nature Erythrocyte Volume Fraction the disease and treatment efficacy. after sexual intercourse, and if within 3 hours after taking the table. Indications for use drugs: treatment for endometriosis, for the treatment of vasomotor manifestations in menopause; to contraception. Side effects and complications in the use of drugs: changes in vaginal bleeding and nature of pathological or severe bleeding, breakthrough bleeding, krovomazannya (these violations are usually normalized to here continuation of treatment), dysmenorrhea, vaginal secretions change, with-m, similar to peredmestrualnoho, sore suits a sense of tension or increase breast; indigestion, bloating, nausea, vomiting, abdominal pain, rashes, various skin disorders (including pruritus, eczema, urticaria, acne, hirsutism, hair loss, pretibial erythema), headache, migraine, dizziness, anxiety, depressed mood, fatigue, palpitations, edema, muscle cramps, changes in body weight, increased appetite, change in libido, blurred vision, intolerance to contact lenses, hypersensitivity reactions.
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