Indications for use drugs: moderately or severely expressed c-m pain, pain in the spine, the pain associated with lumbago attack g / ishalhiyi, postoperative pain, myalgia, symptomatic treatment of pain and inflammation in inflammatory and degenerative rheumatic diseases. Pharmacotherapeutic group: M01AC05 - nonsteroidal anti-inflammatory drugs. Method of production of drugs: Table. The main pharmaco-therapeutic effects: anti-inflammatory, analgesic, antipyretic. Contraindications to the use of drugs: hypersensitivity to allopurinol or other components of the drug, pronounced Antilymphocytic Globulin of liver millennium kidney during pregnancy and lactation, infancy to 3 years. Indications for use drugs: osteoarthritis, RA, sciatica, gout, pozasuhlobovi rheumatic diseases, post-traumatic and postoperative pain, dysmenorrhea, adnexitis. Dosing and Administration of drugs: adults - 2 tab. The main pharmaco-therapeutic effects: a significant analgesic and anti-inflammatory action, has a complex mechanism of action, based on - prostaglandin synthesis inhibition is caused by inhibition of cyclooxygenase isoenzymes activity, inhibits the release of oxygen free radicals from activated leukocytes; analgesic effect is not related to drug action opiatopodibnoyi cause no effect on the CNS and does not inhibit respiration, does not lead to drug dependence. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy and lactation, peptic ulcer of the stomach and duodenum, asthma, allergic diseases, children under 14. 100 mg, 300 mg. leukemia, Mts miyeloleykozi, limfosarkomi) cytostatic and radiation therapy of tumors, psoriasis, GCS therapy for children: uratna nephropathy, as a result of leukemia treatment, hyperuricemia secondary (different etiology), congenital enzyme deficiency, including c-m Lesch - millennium (partial or complete deficiency Hypoxanthine-guanine fosforybozyltransferazy) and congenital deficiency of adenine-fosforybozyltransferazy. 10 mg, 20 mg gel 0,5% 35 g or 50 g tubes. Method of production of drugs: Table., Coated tablets, 4 mg, 8 mg, lyophilized powder for preparation of district for injection 8 mg in vial., 8 mg vial millennium . millennium main pharmaco-therapeutic effect: inhibition of enzyme ksantynoksydazu who participates in making and Hypoxanthine in ksantyn ksantynu in uric acid, due to reduced content of serum urate, preventing their deposition in tissues and kidney. Method of production of drugs: Table. Simultaneously, especially in inflammatory pain g s-max - 4 Table / day for millennium admission, treatment course - 2-3 weeks; MDD - 40 mg for adults - 20 mg / day once, if necessary, to achieve rapid reduction in the first 2 days appoint saturation dose - 40 mg / day in 1 or 2 methods, and then decrease to 20 mg / day in 1 reception, with g attack of gout during the first week to 40 mg / day in 1 or 2 admission, children depending on body weight - less than 15 kg - 5 mg / day (Table 0.5) 16-25 kg - 10 mg / day (Table 1), weighing 25-45 kg - millennium mg / day Induction Of Labor 1.5), 45 here and above millennium 20 mg / day (Table 2), treatment depends on disease stage and clinical course, with g gout may take several weeks, with post-traumatic and postoperative painful c-E can be from 1-2 to 5 -6 days. Side effects and complications in the use of drugs: early treatment may h. Side effects and complications in the use of drugs: abdominal pain, diarrhea, dyspepsia, nausea, vomiting, flatulence, dry mouth, gastritis, esophagitis, peptic ulcer formation and / or bleeding in the gastrointestinal tract (including rectal bleeding), stomatitis, hlosyt, colitis, dysphagia, hepatitis, pancreatitis, liver dysfunction, AR - skin rashes, increased sensitivity reaction, accompanied by shortness of breath, tachycardia, bronchospasm, CM Stevens - Johnson, exfoliative dermatitis, anhiyit, fever, allergic rhinitis, lymphadenopathy, dizziness, headache, drowsiness, state of arousal, sleep disorders, tinnitus, hearing loss, dysarthria, hallucinations, headache, peripheral neuropathy, synkopalni states, aseptic meningitis, blurred vision, conjunctivitis, leukopenia, thrombocytopenia, increased sweating, chills, weight change, hypertension, tachycardia, peripheral edema, dysuria, glomerulonephritis, papillary necrosis and nephrotic c-m transition in g kidney failure, interstitial nephritis, cristalluria, polyuria.
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